Global metabolomics

Brain region mapping using global metabolomics.

Historically, studies of brain metabolism have been based on targeted analyses of a limited number of metabolites. Here we present an untargeted mass spectrometry-based metabolomic strategy that has successfully uncovered differences in a broad array of metabolites across anatomical regions of the mouse brain. The NSG immunodeficient mouse model was chosen because of its ability to undergo huma...

Metabolomics by numbers: acquiring and understanding global metabolite data.

In this postgenomic era, there is a specific need to assign function to orphan genes in order to validate potential targets for drug therapy and to discover new biomarkers of disease. Metabolomics is an emerging field that is complementary to the other ‘omics and proving to have unique advantages. As in transcriptomics or proteomics, a typical metabolic fingerprint or metabolomic experiment is ...

Metabolomics: a global biochemical approach to drug response and disease.

Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in...

Exposing the Exposome with Global Metabolomics andCognitive Computing

Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation.

Nitrogen cycling is a microbial metabolic process essential for global ecological/agricultural balance. To investigate the link between the well-established ammonium and the alternative nitrate assimilation metabolic pathways, global isotope metabolomics was employed to examine three nitrate reducing bacteria using (15)NO3 as a nitrogen source. In contrast to a control (Pseudomonas stutzeri RCH...